At the forefront of innovation
UniVax's overall goal is to develop the first synthetic replicating RNA vaccine against universal influenza (Flu).
While vaccination is the cornerstone of Flu prophylaxis, current inactivated vaccines provide only moderate protection requiring annual updating due to poor long-term immunity and antigenic drift. UniVax will solve this restriction by generating multimeric, self-replicating, universal Flu RNA (RepRNA) vaccines delivered by synthetic, biocompatible, biodegradable carriers. It is targeted to DC receptors due to the essential role of these cells in efficient immune defence development. Co-formulation with novel mucosal adjuvants - also applicable for parenteral vaccination - potentiates development of humoral and cellular immune responses. The latter includes both cytotoxic and the multifunctional T cells related to robust protective T-lymphocyte immunity. Together with the RepRNA providing several rounds of antigen production within DCs, UniVax creates the means for efficacious induction of robust humoral and cell mediated immune (CMI) defences in an SME-dominated concept.